Purine and monoamine metabolites in cerebrospinal fluid: parallel purinergic and monoaminergic activation in depressive illness?

Cerebrospinal Fluid Levels of Monoamine Metabolites in the Epileptic Baboon.

The baboon represents a natural model for genetic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). In this retrospective study, cerebrospinal fluid (CSF) monoamine metabolites and scalp electroencephalography (EEG) were evaluated in 263 baboons of a pedigreed colony. CSF monoamine abnormalities have been linked to reduced seizure thresholds, behavioral abnormalities and SUD...

PS238. Altered balance between monoamine metabolites in human cerebrospinal fluid with major depressive disorder.

Antidepressants and Morphological Plasticity of Monoamine Neurons

In the 1950s, the monoamines 5-hydroxytryptamine (5-HT) (Woolley & Shaw, 1954), noradrenaline (NA) (Vogt, 1954), and dopamine (DA) (Carlsson, 1958) were identified in the brain. After this discovery, it was identified that the tricyclic compound imipramine and the antituberculosis drug iproniazid were effective in the treatment of clinical depression, and that these drugs can increase the extra...

Simultaneous determination of four monoamine metabolites and serotonin in cerebrospinal fluid by "high-performance" liquid chromatography with electrochemical detection; application for patients with Alzheimer's disease.

We describe an optimized, sensitive assay procedure for simultaneously determining 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydroxyphenylacetic acid, and serotonin in human lumbar cerebrospinal fluid. The assay is based on liquid chromatography with an electrochemical detection system equipped with a newly developed, highly sensitive graphite electrode. Before assay, samples are deproteinized wit...

P 78: The Role of Kynurenine Pathway in Suicidal Behavior and Depression

According to global statistics, over 80,000 deaths occur by suicide annually. Up to 90% of complete suicides are based on psychiatric disorders specifically major depressive disorder (MDD) and bipolar disorder. Furthermore high levels of inflammation have been indicated in suicidal patients in both central nervous system and the peripheral blood. Two biological mechanisms that play a key role i...